WitrynaMorphine, codeine, meperidine and propoxyphene are metabolized and cleared via the kidney. Beware oversedation and respiratory depression. Hydromorphone (Dilaudid) …
Analgesics in patients with hepatic impairment: pharmacology and ...
Witryna20 sie 2012 · The drug clearance of a number of opioids, such as morphine, oxycodone, tramadol and alfentanil, might be decreased in moderate or severe hepatic … WitrynaOnly the main-metabolite of cefotaxime shows mentionable antimicrobial activity. With regard to renal insufficiency (creatinine clearance greater than 5 ml/min) dose reduction is not necessary with cefoperazone and with ceftriaxon because of hepatic excretion and with cefotaxime because of metabolism. Publication types English Abstract church suite log in poulner
Chapter 11. Drug Elimination and Hepatic Clearance Applied ...
Witryna1 cze 2001 · Morphine provides the gold standard: in unmodified form its four hour clinical duration of action allows regular review of pain control. Once stable, sustained release formulations reduce dose frequency to once or twice daily. ... However, renal impairment is most important, as it affects clearance of many opioids. Reduced renal … Witryna11 cze 1999 · Abstract. In patients with renal or hepatic failure, the pharmacokinetics of opioids may be affected in several ways, leading to the necessity to correct the dose. … WitrynaMany drugs, including most antiarrhythmics (some of which are now of limited clinical use) are eliminated by the hepatic route. If liver function is impaired, it can be anticipated that hepatic clearance will be delayed, which can lead to more pronounced drug accumulation with multiple dosing. church suite emsworth baptist