Ezn

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August undefined, 2024

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O szkole – Elektroniczne Zakłady Naukowe

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Safety, pharmacokinetics, and activity of EZN-2208, a novel

Ezn

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Tīmeklis2013. gada 15. dec. · Background: Irinotecan is cytotoxic in patients with advanced colorectal cancer (CRC). SN-38 (10-hydroxy-7-ethyl-camptothecin) is the active metabolite of irinotecan. Attachment of polyethylene glycol (PEG) polymer chains (pegylation) to SN-38 (EZN-2208) increases the solubility, exposure, and half-life of … Tīmeklis2013. gada 29. okt. · EZN-4176 is a third-generation antisense oligonucleotide that binds to the hinge region (exon 4) of AR mRNA resulting in full-length AR mRNA degradation and decreased AR protein expression. This ...

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