Chondrocyte subtype

Author: krtr

August undefined, 2024

WebDec 22, 2024 · Results We identified and localized cell types in inner and outer meniscus and found new chondrocyte subtypes associated with degeneration. The observations suggested understandings on how ... WebApr 10, 2024 · Autologous chondrocyte implantation (ACI) involves taking cartilage cells arthroscopically from a non-weight-bearing area of the knee: the cells are then cultured in a laboratory and multiplied, with the cells then being re-implanted into the chondral defect (Figure 1) in the knee 4–6 weeks later, most commonly as an open procedure.The …

Multiscale X-ray phase contrast imaging of human cartilage for ...

WebMay 20, 2024 · Results We identified and localized cell types in inner and outer meniscus, found new chondrocyte subtypes contributing to degeneration, and revealed how cellular compositions, functions, and interactions participated in degeneration. WebJun 21, 2024 · Lawrence Livermore National Laboratory (LLNL) scientists have profiled articular cartilage from healthy and injured mouse knee joints at a single-cell resolution and identified nine chondrocyte subtypes … hsbc opening times middlesbrough

Single-cell RNA sequencing reveals transcriptional changes JIR

WebNov 15, 2024 · Chondrocyte is the only cell type present in mature cartilage and is responsible for repairing damaged cartilage tissue [ 4 ]. Dysfunction of chondrocytes will result in degradation of the matrix, cell death and total loss of cartilage integrity [ 5 ]. WebJun 25, 2024 · Eight subtypes of P2Y family, namely P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14, belong to the G protein-coupled receptors (GPCRs) family and regulate a variety of cellular processes, including proliferation, differentiation, secretion, cell adhesion, and migration. ... Chondrocyte migration enhancement therapy was also … WebNov 15, 2024 · Results: In this study, we characterized the single-cell expression profiling of 480 chondrocyte samples and found hypertrophic chondrocyte (HTC), homeostatic chondrocyte (HomC) and fibrocartilage chondrocyte (FC) respectively. The results of GO and KEGG analysis showed the candidate marker genes made specific function in these … hsbc opening times hull

New research identifies injury-induced molecular changes …

(PDF) Cellular features of localized microenvironments in human ...

WebSep 27, 2024 · The chondrocyte-like subpopulation is the predominant cell type and percentages of this subpopulation increase with disease severity. Despite … WebChondrocyte trajectories analysis and IHC staining revealed that transcription factors including TCF4 were found to be highly up-regulated during the occurrence of SIFK, which might drive the reactive formation of cartilage and fibrous tissue and the activation of endochondral ossification. ... (GSE104782) data, 14 since the chondrocyte subtype ... hsbc opening times ealingWebOct 11, 2011 · Chondrocyte hypertrophy and development of articular cartilage are the major histologic features of femoral head cartilage development (Fig. 2). The prototypic … hsbc opening times oxted

"WebAs expected, all chondrocyte subtypes showed significant enrichment for the ontology terms 'cartilage development' and 'ECM organization' ( Figure 4 A). However, many of the cartilage ECM genes ... " - Chondrocyte subtype

Chondrocyte subtype

Changes in the Chondrocyte and Extracellular Matrix Proteome …

WebJun 7, 2024 · X-PCI is able to resolve the three layers and the architectural organization of cartilage including changes in chondrocyte cell morphology, chondrocyte subgroup distribution and (re-)organization as well as its subtle matrix structures. ... the molecular and functional profiles of various chondrocyte subtypes and understanding the interplay ... WebApr 4, 2024 · The cellular communication among chondrocyte subtypes mediated by signaling pathways, such as PTN, VISFATIN, SPP1, and TGF-β, was selectively …

Did you know?

WebNational Center for Biotechnology Information WebAug 1, 2024 · The chondrocyte is the unique resident cell of articular cartilage and thus solely responsible for ECM composition and regulation. Chondrocyte metabolism is influenced by its micro-environment, and in return influences ECM composition, organization and ultimately the mechanical resilience of cartilage 1, 2, 3.

WebHypertrophic chondrocytes orchestrate endochondral ossification by regulating osteogenic-angiogenic and osteogenic-osteoclastic coupling through the production of vascular endothelial growth factor (VEGF), receptor activator of nuclear factor kappa-B ligand (RANKL) and matrix metallopeptidases-9/13 (MMP-9/13). WebAug 16, 2024 · The chondrocyte subclusters were classified based on their potential regulatory, homeostatic, and effector functions in extracellular matrix (ECM) homeostasis.

WebMar 1, 1995 · Calcium pyrophosphate-deposition disease (CPDD), also called {open_quotes}chondrocalcinosis{close_quotes} or {open_quotes}pseudogout{close_quotes}, is a disorder characterized by the deposition of calcium-containing crystals in joint tissue, which leads to arthritis-like symptoms. WebJan 6, 2024 · Using single-cell RNAseq (scRNA-seq) data from adult mouse knee joint cartilage, we also determined that mature chondrocytes robustly express Loxl2, Loxl3, and Plod2, whereas Lox expression was more restricted to immature chondrocytes/mesenchymal progenitors ( Figure S3B ).

WebMay 10, 2024 · Although studies have reported that three subtypes, including pre-hypertrophic chondrocytes, hypertrophic chondrocytes, and proliferative chondrocytes exist in the ... Prein et al., 2016), new …

WebAug 16, 2024 · The chondrocyte subclusters were classified based on their potential regulatory, homeostatic, and effector functions in extracellular matrix (ECM) … hobby lobby black wall lettersWebChondrocyte subtypes identified in mouse cartilage based on the expression of chondrocyte markers Col2a1, Acan, and Sox9 are shown in black oval. (D) Expression of chondrocyte markers Sox9... hsbc opening times christmas eveWebNov 18, 2024 · Chondrocytes were seeded on the inner side of the membrane (inner bottom group) to prevent direct contact with host cells, while soluble factors were … hsbc opening times dewsburyWeb(A) UMAP plots of various chondrocyte subtypes in human osteoarthritic knee joints. Colors indicate clusters of various cell types with distinct gene expression profiles. (B) Feature plots... hobby lobby black wall clocksWebJun 10, 2024 · We identified six mouse chondrocyte subtypes with highly molecular fidelity to the human subtypes. This study allowed us to elucidate the full extent of … hsbc opening times newcastleWebApr 12, 2024 · 例文. These cells lack the hematopoietic surface markers but express mesenchymal markers. これらの細胞は、造血表面マーカーを欠いていますが、間葉系マーカーを発現しています。. 例文. For example, mesenchymal subtypes were usually defined by the overexpression of mesenchymal markers and underexpression ... hsbc opening times newport iowWebMechanical stress protects against chondrocyte pyroptosis through lipoxin A 4 via synovial macrophage M2 subtype polarization in an osteoarthritis model. Our previous study … hsbc opening times penrith